Creating a future where humankind will no longer suffer from brain aging and degeneration.
Pioneering a new era of advanced medicines to restore and regenerate brain health.
About
Improve lives and extend healthspan.
CNS2 seeks to promote healthy brain function in aging and disease.We harness the power of glia cells to defeat dementia, injury and promote healthy aging through direct cell rejuvenation, neuronal regeneration and enhanced glymphatic waste clearence enabled by forefront epigenetic cell programming strategies.We leverage recent innovations in drug delivery and glymphatic distribution, cell state manipulation, and proprietary humanized translation models to accelerate the development of next-gen curative genetic CNS medicines.
Science
Harnessing glia cells to reverse aging and degeneration.
Glia Progenitor Cells (GPCs) are the critical component of the human brain, responsible for generating astrocytes and myelinating oligodendrocytes throughout life.These cells are highly proliferative in early development and youth, but their ability to divide and replenish decreases substantially with age and in disease, making them a critical driver of many neurological disorders and of aging.Thus their rejuvenation, and even directed differentiation into missing cell types, can profoundly impact neurological diseases.Additionally, recent research has shown that the glymphatic gystem, controlled by glia, clears the brain of metabolic waste and therefore plays a crucial role in healthy brain function.
The ties that bind aging, glymphatic clearance, protein aggregation and sleep have shed new light on the pathogenesis of a broad range of neurodegenerative diseases including Alzheimer’s Disease, and have led us to develop novel treatments that target glymphatic clearance to slow or prevent disease progression.Our strategies for programming and rejuvenating aged or dysfunctional human GPCs thus enable them to compensate effectively for both the ill effects of aging and dementias caused by both neuronal loss, cell senesce or failure of clearing protein waste.
Improve lives and enable healthy aging.
Approach
Building solutions to restore cell health and resilience, and fight the slow degeneration of neurons.
CNS2 utilizes multiomic strategies, next-gen humanized modeling platforms and reprogramming modalities to predict efficacy of human glia-directed therapeutics and restore brain health.We will launch our mission of rejuvenating and regenerating the aged and diseased brain by operating on three synergistic mechanisms:
1
Rejuvenate aged and senescent glia in aging and disease to restore myelin, white matter integrity and synaptic homeostasis.
2
Regenerate lost neuronal circuits via in situ reprogramming of GPCs.
3
Restore the aging brain’s waste-clearing system (the glymphatic system) while utilizing it for therapeutic delivery.
Founders
Founded by forward-thinking pioneers of CNS regeneration and rejuvenation.
Dr. Goldman is Distinguished Professor of neuroscience and neurology at the University of Rochester Medical Center, and serves as Co-Director of Center for Translational Neuromedicine. He is also Dean Zutes Chair in Biology of the Aging Brain.
Dr. Nedergaard is Dean's Professor of Neurology and Neuroscience. She serves as the Co-Director of Center for Translational Neuromedicine.
Dr. Trojel-Hansen is an experienced serial entrepreneur and adjunct assistant professor at Center for Translational Neuromedicine.
Scientific Advisors
World-class Advisory Board.
Careers
At CNS2 we are always looking for talented and motivated individuals to join our team. We offer a dynamic work environment and opportunities for career growth and development. If you are interested in joining our team, please contact us.
News
At CNS2 we're dedicated to enhancing brain health and function as we age. Our innovative solutions are backed by rigorous scientific research, and our team of experts is committed to providing safe, effective, and easy-to-use tools and resources for optimal brain aging.
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